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利用冷加压试验研究偏头痛患者的血管神经偶联机制

发布日期【2018-09-30】 已浏览【】次
利用冷加压试验研究偏头痛患者的血管神经偶联机制
摘自:Cephalalgia 0(0) 1–10  International Headache Society 2014
作者:Andrej Fabjan, Fajko F Bajrovic,Bojan Musizza,Jernej Vidmar, Martin Strucl1 and Marjan Zalete

摘要:偏头痛患者神经血管耦合改变可能是脑干核团调节功能受损的结果。利用冷加压试验,可以刺激脑干核团。本文测量了偏头痛患者的冷加压试验前后视觉诱发的脑血流速度变异(visually evoked cerebral blood flow velocity response,VEFR)

Introduction
In recent years, migraine has been viewed as a neurovascular disorder (1). Neuroradiological studies have shown that patients with migraine have an increased incidence of ischemic-like lesions, especially in the territory of posterior circulation (2). Clinical studies have suggested that migraine is an independent risk factor for ischemic stroke (3). The etiology of ischemic-like lesions in migraine is debated; nevertheless, the impairment of cerebrovascular regulation seems to be an important issue in migraine pathophysiology (4).
Single-photon emission tomography and magnetic resonance imaging studies have shown interictal perfusion changes in patients with migraine (5,6).Additionally, increased interictal cerebrovascular reactivity in patients with migraine has been shown
by functional transcranial Doppler, a method with good temporal resolution (7). It has been proposed that altered cerebrovascular reactivity to metabolic demand of active brain tissue in migraineurs is a consequence of impaired function of modulatory brainstem nuclei,which are an important source of perivascular……。
Participants and methods
……CBFV was measured using two 2MHz Delica EMS-9U transcranial Doppler ultrasound (TCD) probes (Shenzen Delicate Electronics, Shenzen, China……。

Study of neurovascular coupling during cold pressor test in patients with migraine.pdf